迷你青春期内外部生殖器的发展:它与体质生长或生殖激素有关吗?
Hazal Arıkan Gacemer1, Busra Gurpinar Tosun2, Didem Helvacioglu2
1Department of Pediatrics, Marmara University School of Medicine, 34841, Istanbul, Turkey.
European journal of pediatrics
|December 22, 2023
概括
在婴儿时期的迷你青春期,男性外部生殖器的发育与体质生长有关,而不是荷尔蒙. 更高的体重与男性的丸激素水平有负相关性,类似于晚年青春期.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖生物学 生殖生物学
- 人类成长和发展 人类成长和发展
背景情况:
- 在婴儿期 (迷你青春期) 中,下丘脑-垂体-淋巴结核 (HPG) 轴是活跃的.
- 人体生长和生殖荷尔蒙在迷你青春期对外部生殖器发育的影响尚未完全理解.
- 现有的研究表明,脂肪组织和丸激素在生命后期阶段之间存在反向关系.
研究的目的:
- 调查体质生长和生殖激素对婴儿在迷你青春期内的外部生殖器发育的影响.
- 探索人类测量测量,激素水平和1-4个月龄的健康婴儿的生殖器发育之间的关系.
主要方法:
- 在148名1至4个月的健康婴儿 (74名女性) 中评估了人体测量数据 (体重,身高,BMI) 和青春期评估.
- 测量了FSH,LH,DHEAS,A4,SHBG,E2,inhibin-B,T和AMH的血清含量. 这是一个很好的结果.
- 计算的自由性激素指数 (男孩的T/SHBG,女孩的E2/SHBG).
主要成果:
- 阴茎长度与体重,身高和AMH有积极的相关性,但与没有相关性.
- 在男性中,体重较高与血清LH和自由水平 (T/SHBG) 有负相关性,体重-SDS与水平有负相关性.
- 丸大小和乳房阶段与荷尔蒙或人类参数没有相关性.
结论:
- 在迷你青春期的男性外部生殖器发育主要与体质生长有关,而不是生殖激素.
- 婴儿期体重增加与男性的丸激素水平有负面联系,反映了晚年青春期阶段所见的模式.
- 在男性中观察到的体质生长和生殖器发育之间的关系,在女性中在迷你青春期没有发现.
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