对肝细胞癌患者心血管死亡竞争风险的分析:基于人口的研究
Lizhi Cao1,2, Xiaoying Wang3, Yuzhong Yan3
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Medicine
|December 22, 2023
概括
肝细胞癌 (HCC) 患者面临显著更高的心血管疾病 (CVD) 死亡风险. 早期发现和治疗心血管疾病对于改善HCC患者的生存率至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是肝细胞癌 (HCC) 患者的主要死亡原因.
- 了解HCC中心血管疾病的特定风险对于改善患者的治疗结果至关重要.
研究的目的:
- 在被诊断为HCC的患者中调查心血管疾病的并发症效应.
- 与一般人群相比,量化HCC患者心血管死亡风险的过高.
主要方法:
- 在HCC患者 (2000年至2014年) 与美国普通人口之间,心血管死亡率的比较.
- 计算标准化死亡率 (SMR) 以评估相对风险.
- 使用细灰测试和竞争性风险模型估计心血管死亡的累积发病率.
主要成果:
- 在HCC患者中,心血管疾病的总体SMR为11.15,表明风险显著增加.
- 年轻的HCC患者 (<55岁) 与老年患者 (≥75岁,SMR1.86) 相比,面临着更高的SMR (56.19).
- 在HCC患者中,心血管疾病的独立风险因素包括年龄,瘤等级,大小,SEER阶段和手术状态.
结论:
- 患有HCC的患者患心血管疾病和死于心血管疾病的风险明显增加.
- 在HCC治疗期间和之后,加强预防性查和心血管疾病的积极管理至关重要.
- 解决心血管并发症可以改善肝细胞癌患者的整体存活率.
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