在患有1型糖尿病和/或腹腔疾病的儿童之间,B细胞子集的转移
Andrea Tompa1,2, Maria Faresjö1,3
1Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University, Jönköping, Sweden.
Clinical and experimental immunology
|December 22, 2023
概括
与单次诊断的儿童相比,患有1型糖尿病和腹腔疾病的儿童有改变的B细胞模式,具有更多的记忆B细胞和调节性B细胞 (Bregs). 这种转变会影响自身免疫性疾病的发展.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 1型糖尿病 (T1D) 和腹腔疾病 (C) 是一种经常在儿童中同时发生的自身免疫性疾病.
- 周围B细胞子集模式可能在单独或联合诊断T1D和C的儿童中不同.
- 了解这些差异对于阐明这些自身免疫性疾病的病理生理学至关重要.
研究的目的:
- 描述和比较T1D和C联合诊断的儿童与单一诊断的儿童的外围B细胞子集模式.
- 识别特定的B细胞子集 (过渡性,天真,记忆) 和调控性B细胞 (Bregs),这些B细胞在组合T1D和C组中发生变化.
主要方法:
- 流细胞计用于分析基于分化/成熟标记的B细胞子集.
- 通过使用特定的细胞表面标记物 (例如CD24,CD38,CD27,CD1d,CD5) 来识别过渡性和记忆性Bregs.
- 在诊断组中量化和比较了天真,记忆和调节性B细胞的百分比.
主要成果:
- 患有T1D和C结合的儿童表现出整体外围B细胞子集的减少.
- 与单独的T1D或C相比,组合组显示了更高的B细胞和Bregs记忆百分比,包括激活子集.
- 在组合组中观察到更低的纯粹B细胞百分比和更高的记忆B细胞百分比,以及改变的CD39表达模式.
结论:
- 结合T1D和C的儿童的外围B细胞区表现出一个独特的模式,其特点是增加记忆B细胞和Bregs.
- 这些B细胞子集的变化表明了免疫谱的转变,这可能会影响同时发生的自身免疫性疾病的病理生理学.
- 对这些免疫学差异的进一步研究是有必要的,以了解它们对疾病进展和潜在治疗点的影响.
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