无症状和症状COVID-19对急性缺血性中风重血管化结果的影响
Davide Strambo1, João Pedro Marto2, George Ntaios3
1Stroke Center, Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, University of Lausanne, Switzerland (D.S., P.M.).
Stroke
|December 22, 2023
概括
COVID-19增加了出血风险,并加剧了急性缺血性中风 (AIS) 患者接受再血管化的结果. 无论是无症状还是有症状的COVID-19患者都面临更高的风险,有症状的病例显示出更严重的结果和较差的再治疗率.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 心血管研究研究心血管研究
背景情况:
- COVID-19与急性缺血性中风 (AIS) 患者的出血风险增加和不良结果有关,这些患者正在接受再血管化.
- 感染症状 (无症状与有症状) 对这些结果的影响需要进一步调查.
研究的目的:
- 评估在无症状COVID-19 (AS-COVID) 和症状COVID-19 (S-COVID) 的AIS患者中重新血管化治疗的安全性和结果.
- 为了比较COVID阴性对照,AS-COVID和S-COVID组之间的结果.
主要方法:
- 在2020-2021年期间接受治疗的15124名AIS患者的国际多中心回顾性队列研究.
- 患者进行了SARS-CoV-2检测,并分为COVID-负,AS-COVID和S-COVID组.
- 评估的结果包括症状性内出血,死亡率和3个月的残疾 (修改的兰金级).
主要成果:
- 与对照组相比,AS-COVID和S-COVID组的症状性内出血率都较高.
- 在S-COVID患者中,24小时和3个月死亡率显著增加.
- COVID-19患者经历了更糟糕的3个月残疾,特别是症状病例;S-COVID也具有较低的成功再通道化率.
结论:
- 无论是无症状还是症状的COVID-19都会对重新血管化的AIS患者的出血风险和临床结果产生负面影响.
- 症状性COVID-19与更严重的结果有关,包括较高的死亡率和降低的再通道成功率.
- 无论症状状况如何,SARS-CoV-2感染显著影响了重血管化的AIS的预后.
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