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Updated: Jul 7, 2025

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
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蛋白激酶C三角酶调节单核细胞,并阻碍了癌症免疫治疗的反应

Mehdi Chaib1, Jeremiah R Holt2, Emilie L Fisher3

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Science advances
|December 22, 2023
PubMed
概括

在单核细胞 (MPs) 中准蛋白激酶C三角酶 (PKCδ) 可以增强抗PD-1疗法. 在MP中删除PKCδ可以减少瘤生长,增强抗瘤免疫力,改善对免疫检查点封锁的反应.

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