一个振动的可摄入生物电子刺激器调节胃伸展受体,以实现虚幻的腹感
Shriya S Srinivasan1,2,3,4, Amro Alshareef1,2,3, Alexandria Hwang1,2
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science advances
|December 22, 2023
概括
一种新的可摄入装置,即振动可摄入生物电子刺激器 (VIBES) 药丸,激活胃伸展受体,以减少食物摄入量和体重增加. 这种非侵入性技术为肥胖管理提供了一种新的方法.
科学领域:
- 生物医学工程 生物医学工程
- 胃肠病学 胃肠病学
- 神经科学是一个神经科学.
背景情况:
- 由于当前治疗方法的局限性,肥胖管理具有挑战性,通常需要侵入性手术或高患者坚持.
- 胃机械受体通过感知胃膨胀和通过阴道神经发出信号,在腹中发挥着至关重要的作用.
- 激活这些受体为控制食欲提供了一个潜在的非侵入性策略.
研究的目的:
- 开发一种新的光刺激方式,专门激活胃伸展受体.
- 为了创建一个可以吞的装置,能够诱导模仿机械膨胀的阴道 afferent 响应.
- 研究这项技术在管理营养障碍和肥胖方面的潜力.
主要方法:
- 振动可摄入生物电子刺激器 (VIBES) 药丸的设计和开发,是一种可摄入的设备.
- 使用光线振动刺激来激活胃机械受体和粘膜受体.
- 在108餐的猪中评估VIBES疗效,评估食物摄入量和体重增加.
主要成果:
- 在猪中,VIBES药丸持续减少了大约40%的食物摄入量 (P < 0.0001).
- 与对照组相比,该设备显著降低了体重增加率 (P <0.05).
- 振动刺激诱导了荷尔蒙代谢反应,表明一个的状态.
结论:
- VIBES药丸有效地激活胃机械受体,导致食物消耗减少和体重增加.
- 这种可摄入的技术代表了对肥胖和营养障碍的有希望的非侵入性治疗方法.
- 利用机械受体生物学可以改变患有这些疾病的患者的管理.
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