Eu3+-修改的共价有机框架用于检测乙烯基化物单体暴露生物标志物
Yinsheng Liu1, Mingyue Wang1, Yingfei Hui1
1Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education; Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection (NWNU), Ministry of Education; Key Lab of Bioelectrochemistry and Environmental Analysis of Gansu Province; Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P.R. China.
ACS sensors
|December 22, 2023
概括
一个新的比度光传感器检测了硫基甘油酸 (TDGA),这是一种对乙烯基化物单体 (VCM) 暴露的生物标志物. 这种新的共价有机框架 (COF) 系统为环境监测提供了高灵敏度和选择性.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 环境科学 环境科学
背景情况:
- 乙烯基化物单体 (VCM) 是一种普遍存在的工业污染物,对人类有很大的暴露.
- 尿液中的滴滴糖酸 (TDGA) 作为VCM暴露的特定生物标志物.
- 准确的TDGA检测对于了解VCM相关的健康风险和疾病诊断至关重要.
研究的目的:
- 开发一种高灵敏性和选择性比度光传感器用于TDGA检测.
- 建立用于TDGA分析的第一个基于共价有机框架 (COF) 的系统.
- 提供可靠的工具来监测VCM暴露和识别风险人群.
主要方法:
- 一个比度光传感器的设计和合成:DPA/Eu@PY-DHPB-COF-COOH.
- 使用Eu3+作为一个桥梁,在2,6-滴酸 (DPA) 和COF之间.
- 利用比度光的自我校准优势,进行精确的测量.
主要成果:
- 开发的传感器对TDGA具有很高的选择性和灵敏度.
- 计量光方法确保了内置的自我校准,对外部干扰进行校正.
- 这代表了首个基于COF的传感器,专门设计用于TDGA检测.
结论:
- 新的DPA/Eu@PY-DHPB-COF-COOH传感器为TDGA量化提供了一个强大的平台.
- 这项工作在VCM暴露监测方面取得了重大进展.
- 这些发现为未来开发复杂的TDGA传感器奠定了基础.
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