普雷加巴林产生的效果类似于 gabapentin 在猫的麻醉前镇静
Rahul D Madan1, Alessia Cenani2, Elizabeth Montgomery1
11Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Journal of the American Veterinary Medical Association
|December 22, 2023
概括
口服普雷加巴林和 gabapentin 在猫中提供可比的外科手术后镇静作用. 这两种药物都对镇静质量和麻醉恢复产生了类似的影响,很少需要救援镇静或妄想的发生.
科学领域:
- 兽医麻醉学 兽医麻醉学
- 药理学 药理学是指药理学的学科.
- 小动物医学 小动物医学
背景情况:
- 术前镇静对于猫科动物手术患者至关重要.
- 口服普雷加巴林和 gabapentin 是潜在的辅助镇静剂.
- 对猫的比较疗效数据有限.
研究的目的:
- 为了比较口服普雷加巴林和 gabapentin 在猫的术后镇静.
- 为了评估镇静质量和麻醉恢复时间.
- 评估对生理学参数和出现妄想的影响.
主要方法:
- 随机化,前性临床试验涉及50只健康的猫.
- 猫接受了布普伦诺芬,然后是口服普雷加巴林 (4毫克/公斤) 或 gabapentin (10毫克/公斤).
- 被盲目的兽医评估了镇静,麻醉恢复,生理参数和妄想.
主要成果:
- 在pregabalin和gabapentin组之间,在生理参数或镇静得分上没有发现显著差异.
- 在两组治疗中,需要救援镇静和出现妄想的发生率是罕见的和相似的.
- 口服普雷加巴林和 gabapentin 两种药物都提供了可比的术后镇静作用.
结论:
- 口服普雷加巴林和 gabapentin 在被研究的剂量中同样有效,作为猫的辅助术前镇静剂.
- 这两种药物在生理参数和出现妄想方面都具有相似的安全性.
- 这些发现支持使用普雷加巴林或 gabapentin 猫的外科静止治疗.
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