权重单步GWAS确定了与中国黄色羽毛种群的尸体特征相关的候选基因
Rongyang Pan1, Lin Qi2, Zhenqiang Xu2
1State Key Laboratory of Livestock and Poultry Breeding, & Lingnan Guangdong Laboratory of Agriculture, South China Agricultural University, Guangzhou 510642, China; Guangdong Xugang Yellow Poultry Seed Industry Group Co., Ltd, Jiangmen City, Guangdong Province, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affair, South China Agricultural University, Guangzhou 510642, China; Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
这项研究确定了关键的基因组区域和候选基因,这些基因影响肉尸体的特征,如体重和肌肉发育. 这些发现有助于优质肉的基因改进.
科学领域:
- 动物遗传学动物遗传学
- 量化遗传学 量化遗传学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 肉的尸体特征是复杂的,受到众多基因的影响.
- 了解这些特征的遗传基础对于育种计划至关重要.
研究的目的:
- 确定与中国黄色羽毛的九个重要尸体特征相关的基因组区域和候选基因.
- 为遗传改进提供对尸体特征遗传架构的见解.
主要方法:
- 在1338只肉上进行了权重单步全基因组关联研究 (wssGWAS).
- 现型,血统和基因型数据 (600K SNP芯片) 用于关联分析.
- 进行了基因本体学和基因和基因组丰富分析的京都百科全书.
主要成果:
- 显著的基因组区域解释了2.38%至5.09%的9个特征的表型变异.
- 染色体1上含有RELT和FAM168A的特定区域 (194.53-194.63Mb) 与尸体重量和相关特征有关.
- 确定了参与肌肉发育,脂肪沉积和血管发育的候选基因.
结论:
- 整合表型,基因型和血统数据可促进肉尸体特征的遗传改进.
- 已确定的基因组区域和候选基因为培育高质量的肉提供了有价值的目标.
- 这项研究增强了对经济上重要的体特征背后的遗传结构的理解.
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