胎盘生长因子在11-14周怀孕的参考范围在印度尼西亚
Detty Siti Nurdiati1, Aditya Kusuma2, Adly Nanda Al Fattah3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia.
Placenta
|December 22, 2023
概括
这项研究创建了一个胎盘生长因子 (PLGF) 参考图表,用于11-14周的印尼怀孕. PLGF水平受到皇冠-长 (CRL) 的影响,而不是母亲因素.
科学领域:
- 孕产妇和胎儿的医学
- 生物化学 生物化学
- 遗传学 遗传学 是一个
背景情况:
- 准确的胎盘生长因子 (PLGF) 参考范围对于早期怀孕的评估至关重要.
- 建立特定人口的图表可以解释种族和地理差异.
- 印度尼西亚人口缺乏第一季度的PLGF参考数据.
研究的目的:
- 为印尼人口在妊娠11-14周之间开发胎盘生长因子 (PLGF) 值的参考图表.
- 分析母体特征和冠长度 (CRL) 对PLGF水平的影响.
- 根据CRL创建一个调整的PLGF多重中位数 (MoM) 参考图.
主要方法:
- 一项对2062名怀孕第一季度 (怀孕11-14周) 的妇女的观察性研究.
- 收集母亲的特征,生物物理测试和血清PLGF水平.
- 使用线性和逻辑回归分析来调整PLGF MoM对母因子和CRL的调整,开发一个参考图表.
主要成果:
- 中位数PLGF水平为50.38 pg/ml (范围:1.09-265.20 pg/ml) 和中位数PLGFMoM为1.00 (范围:0.02-4.80).
- 多变量分析表明,PLGF MoM没有受到母亲因素 (年龄,平价,吸烟,糖尿病,BMI,体重,身高) 的显著影响.
- 一个针对CRL进行调整的PLGF MoM参考图成功地使用二次线性回归进行了开发.
结论:
- 怀孕11-14周的胎盘生长因子 (PLGF) 水平主要受到印尼人口的冠状长度 (CRL) 的影响,而不是母亲的特征.
- 开发的参考图表提供了一个有价值的工具来评估PLGF在这个特定的人口.
- 需要进一步的研究来评估PLGF的实用性,与其他标记物一起,用于印尼的查目的.
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