在全国范围内,大脑内出血的发病率和体积之间的日间模式
Anirudh Sreekrishnan1, Ronda Lun1, Gregory W Albers1
1Department of Neurology, Stanford Hospital, Palo Alto, CA, United States.
概括
脑内出血 (ICH) 的体积在夜间发生时更大. 这项研究使用大量自动脑部扫描数据集验证了ICH发生率和血瘤体积的日间趋势.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 脑内出血 (ICH) 呈现季节性和白天性模式.
- 在夜间出血期间,ICH的严重程度可能会更大.
- 凝血,血压和睡眠-清醒周期的节律性可能会影响ICH.
研究的目的:
- 在一个大型的全国数据库中验证ICH发病率的日间趋势.
- 根据图像采集时间,评估血液瘤体积的差异.
主要方法:
- 利用来自美国医院 (2020-2021) 的序列非对比头部CT (NCHCT) 数据.
- 使用自动成像软件 (iSchemaView) 进行ICH检测.
- 不包括25岁以上的患者,血瘤体积≥100毫升或≤0.4毫升.
- 分类成像时间为晚上 (23:00-06:59),白天 (07:00-14:59) 和晚上 (15:00-22:59).
主要成果:
- 包括19397次扫描,ICH的中位数体积为2.9毫升.
- 峰值成像发生在中午左右.
- 血液瘤体积在不同时间点有显著差异 (p=0.003).
- 在夜间的ICH (平均. 14.2毫升) 比白天 (12.9毫升) 或晚上 (13.0毫升) ICHs.
结论:
- 在现实世界,多站点数据集中,确认了ICH发病率的日间趋势.
- 根据成像时间检测到ICH体积的微妙差异.
- 需要进一步的研究来了解潜在的机制.
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