脑卒中后:从临床预测因素到可能的机制
Sofia Freiman1, W Allen Hauser2, Flora Rider3
1Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department of Moscow, Moscow, Russian Federation; Laboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russian Federation.
Epilepsy research
|December 22, 2023
概括
脑卒中后 (PSE) 影响大约6%的中风幸存者,皮质病变和早期是关键的危险因素. 需要进一步的研究来了解其原因,并制定有效的预防策略.
科学领域:
- 神经学 神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 脑卒中医学 脑卒中医学
背景情况:
- 脑卒中是老年人新发的主要原因.
- 脑卒中后 (PSE) 占老年人未引起的发作的很大一部分.
- 本综述审查了PSE的流行病学,风险因素,机制和管理.
研究的目的:
- 审查目前对中风后 (PSE) 的理解.
- 确定PSE的风险因素,潜在机制以及潜在的预防和治疗策略.
- 综合现有的关于日益增长的PSE研究领域的文献.
主要方法:
- 使用PubMed和Cochrane图书馆数据库进行全面的文献搜索.
- 关键词包括"中风,"",中风,"",中风后"和"中风后".
- 从选定的文章和评论中手动分析参考列表,以确定其他相关研究.
主要成果:
- 脑卒中后 (PSE) 发生在大约6%的中风患者中.
- 关键的PSE风险因素包括皮质病变,中风严重程度,年轻年龄和早期发作 (ES).
- 由于抗和神经保护作用,他类药物显示出PSE预防的潜力;AED单一治疗可以控制发作,但不能防止焦点形成.
结论:
- 进一步的研究对于阐明PSE的病理生理学至关重要.
- 开发治疗中风后的有效预防策略需要继续进行研究.
- 了解早期发作在发育中的作用对于未来的干预至关重要.
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