在没有痴呆症的记忆诊所患者中,终身压力,认知和白天皮质醇
Jasper Holleman1, Ingemar Kåreholt2, Malin Aspö3
1Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Karolinska Vägen 37A - QA32, Stockholm, Solna 17164, Sweden.
Archives of gerontology and geriatrics
|December 22, 2023
概括
生活压力会影响老年人的认知功能,影响因压力因素的生命阶段而异. 皮质醇模式似乎没有调解这些认知关联.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 慢性压力及其对认知功能及其对皮质醇等生理标志物的影响,是年长成年人面临的重大问题.
- 了解压力生活事件 (SLEs) 和对认知的感知压力的长期影响对于健康老龄化至关重要.
研究的目的:
- 在老年人中调查生命过程压力,认知表现和白天皮质醇模式之间的关系.
- 探索日间皮质醇模式和感知压力是否调解了生命过程压力和认知之间的联系.
主要方法:
- 评估了来自瑞典记忆诊所队列的127名非痴呆症参与者.
- 横截面分析使用线性回归来检查慢性压力测量 (感知压力,SLE),认知领域和白天皮质醇模式之间的关联.
主要成果:
- 较高的人生压力生活事件 (SLEs) 与较差的记忆,工作记忆和处理速度相关.
- 童年时期的压力生活事件 (SLEs) 与工作记忆和处理速度的恶化有关,而晚年SLEs与更好的整体认知和感知推理有关.
- 感知到的压力与平整的白天皮质醇斜率有关,但不是直接与认知功能有关;在压力标志物和认知之间没有发现调解.
结论:
- 压力生活事件 (SLE) 对认知的影响取决于事件的时间.
- 这些关联似乎独立于晚年皮质醇失调.
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