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生命史参数,种群动态和转录组调节的变化 Brachionus plicatilis 暴露于三桑

YunhongYang¹, Tianyue Mao¹, Yifan Ding¹

¹Jiangsu Province Key Laboratory for Fisheries Live Food, School of Marine Science and Engineering, Nanjing Normal University, No. 2 Xuelin Rd, Nanjing 210023, People's Republic of China.

Marine pollution bulletin

|December 22, 2023

概括

低剂量的克洛桑 (TCS) 提高了鱼的繁殖能力,但高度会损害水生生物. 转录组分析显示,TCS对基因表达的影响与状功能和焦点粘附通路有关.

科学领域:

环境毒理学环境毒理学
水生生态学水生生态学
分子生物学分子生物学

背景情况:

特里克洛桑 (TCS) 是一种具有脂友性质,半衰期长,生物缩倾向的抗菌剂,具有生态风险.
水生生物对TCS等环境污染物很脆弱,因此需要对其毒理影响进行研究.

研究的目的:

为了研究三 (TCS) 对水生生物 Brachionus plicatilis 的毒性.
评估TCS对生命史参数,种群动态和转录组调节的影响.

主要方法:

暴露于不同度的TCS (25, 100, 200μg/L) 的Brachionus plicatilis.
评估生命史参数 (生育能力,生殖期) 和人口动态.
转录组分析以确定基因表达变化.

主要成果:

25μg/L的TCS促进了的生育能力;更高的度 (100,200μg/L) 抑制了它.
200μg/L的TCS度显著缩短了生殖期,并延长了后生殖期.
高的TCS度对人口增长和寿命表参数产生了负面影响.
转录组分析显示,TCS调节了参与组织,组装和焦点粘附通路的基因.

结论:

特里克洛桑对Brachionus plicatilis的繁殖和种群动态表现出剂量依赖的影响.
状功能中的基因表达调节和焦点粘附通路是水生生物中TCS毒性的关键机制.
这些发现凸显了水生生态系统中与triclosan污染相关的生态风险.

关键词:

它们是Brachionus plicatilis的种子.生命史生命史生命史人口动态人口动态转录的规则转录的规则三克洛桑是一种三克洛桑.

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