相关实验视频

Updated: Jul 7, 2025

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene
08:22

A Robust Polymerase Chain Reaction-based Assay for Quantifying Cytosine-guanine-guanine Trinucleotide Repeats in Fragile X Mental Retardation-1 Gene

Published on: September 16, 2019

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在脆弱X综合征中长突触基因的空间协调异色素化

Thomas Malachowski1, Keerthivasan Raanin Chandradoss1, Ravi Boya1

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.

Cell
|December 22, 2023
PubMed
概括

在脆弱X综合征 (FXS) 中,短串重复 (STR) 不稳定导致大H3K9me3域,改变基因组结构和基因表达. 通过CRISPR编辑这些扩展, 恢复了正常的染色体和基因活动.

关键词:
关于CRISPR的研究鱼类的DNA这里是H-C染色体表观遗传学脆弱X综合征不同染色素高级基因组折叠重复扩张的障碍短时间的双重重复在拓上关联域

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Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein10:59

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Heterochromatin02:38

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