德罗斯菲拉上皮组织的基底点结对形态遗传力做出反应,并调节河马信号传递
Benjamin Kroeger1, Samuel A Manning1, Yoshana Fonseka2
1Department of Anatomy and Developmental Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia; Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia.
Developmental cell
|December 22, 2023
概括
机械力量通过河马通路调节器官大小. 在Drosophila上皮组织中,一个新的基底点连接枢纽将细胞骨张力与Hippo信号结合起来,控制器官生长.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 机械生物学 机械生物学
背景情况:
- 器官的大小受到各种因素的严格调节,包括机械力.
- 河马通路是一个关键的信号网络,参与控制器官大小.
- 在生长的上皮组织中细胞骨张力通过改变蛋白质定位来影响Hippo信号.
研究的目的:
- 确定新的信号枢纽,这些枢纽可以调节机械力量对Hippo路径的影响.
- 研究细胞骨张力在组织形态发生过程中调节Hippo通路活动中的作用.
- 了解机械线索如何转化为控制器官生长的生化信号.
主要方法:
- 利用Drosophila上皮组织作为研究器官生长和发育的模型系统.
- 研究了Hippo路径组件在特定细胞结点的局部化和功能.
- 分析了细胞骨张力和焦点粘附对基底点结动力学和Hippo信号的影响.
主要成果:
- 发现了一个以前未经描述的河马信号枢纽,位于基底点结点.
- 基底点结会招募激酶 (Hippo路径组件),隔离它并防止其激活.
- 这些结点对细胞骨张力敏感,它们的丰富性受到焦点粘附和actomyosin网络的影响.
结论:
- 基底点结作为关键接口,将机械力与Hippo路径调节相合.
- 这种机制使细胞能够感知和响应组织紧张,从而控制器官的大小.
- 这些发现为机械线索如何融入发育信号通路提供了新的见解.
相关概念视频
02:33Hedgehog Signaling Pathway
7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
03:14Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
01:03Anchoring Junctions
3.8K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
3.8K
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K