在接受癌症治疗的患者中突然心脏死亡的风险
Saadia Sherazi1, Arpan Patel2, Kimberly Hsu1
1Clinical Cardiovascular Research Center, Division of Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
The American journal of cardiology
|December 22, 2023
概括
癌症治疗可以增加心脏突然死亡 (SCD) 的风险. 年轻的患者,心力衰竭史患者和肺癌患者在治疗期间面临更高的SCD风险.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 在接受治疗的癌症患者中,突然心脏死亡 (SCD) 的风险尚不清楚.
- 癌症疗法可能会影响心血管健康,需要进行风险评估.
研究的目的:
- 评估癌症治疗的前六个月内SCD的风险.
- 在接受活跃癌症治疗的患者中识别SCD的风险因素 (RF).
主要方法:
- 在2011年至2020年期间接受治疗的8356名患者的回顾性队列研究.
- 主要终点:癌症治疗开始后6个月内发生SCD.
- 多变量考克斯回归分析以确定独立的RF.
主要成果:
- 6个月后SCD的累积概率为0.6%,发现了51例病例.
- 对SCD的独立RF包括年龄<74岁,心脏不全史和肺癌.
- 与0或1RF (0.5%) 的患者相比,具有≥2RF的患者的累积SCD概率 (1.6%) 显著更高 (逻辑等级p <0.001).
结论:
- 积极的癌症治疗与SCD的风险增加有关.
- 这种风险在年轻的患者 (<74岁),有心力衰竭史的患者和肺癌患者中更为明显.
- 需要进一步的研究来制定高风险人群的预防策略.
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