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在神经退行性疾病中,细胞循环调节器的翻译后修饰及其治疗方法之间的选

Neetu Rani¹, Mehar Sahu¹, Rashmi K Ambasta²

¹Molecular Neuroscience and Functional Genomics Laboratory, Department of Biotechnology, Delhi Technological University (Formerly DCE), Delhi 110042.

Ageing research reviews

|December 22, 2023

概括

在神经退行性疾病 (NDD) 中,细胞循环调节者的转化后修饰 (PTM) 是至关重要的. 针对这些PTM为阿尔茨海默氏症等疾病提供了一个有前途的治疗策略.

科学领域:

分子生物学分子生物学
神经科学是一个神经科学.
生物化学生物化学

背景情况:

由于复杂的原因,神经退行性疾病 (NDD) 如阿尔茨海默氏症和帕金森症缺乏治疗方法.
细胞循环调节者的转化后修饰 (PTM) 越来越多地被认为在NDD中起作用.
了解PTM为神经退行症提供了潜在的治疗点.

研究的目的:

审查PTMs在神经退行性疾病中的细胞循环调节者的作用.
探索针对这些PTM用于NDD治疗的治疗潜力.

主要方法:

关于影响环林,CDK和CDK抑制剂的PTM (酸化,乙化,无化,SUMOylation,糖化,尼迪化) 的文献综述.
在NDDs的背景下,分析神经元细胞周期控制中PTM失调的分析.
检查涉及CDK抑制剂和PTM调节的治疗策略.

主要成果:

细胞循环调节器上PTMs的失调有助于NDD中神经元细胞循环活动异常.
PTMs影响涉及CDK和CDK抑制剂的信号级联,甚至在转移后的神经元中.
准PTMs为恢复NDD中神经元功能提供了一个可行的治疗途径.

结论:

PTMs关键调节细胞循环蛋白质,这些蛋白质与神经退行性疾病的发病有关.
调节PTM对开发新疗法来逆转NDD中神经元功能障碍具有前景.
对PTM机制的进一步研究可能会为阿尔茨海默病,帕金森病和亨廷顿病提供新的治疗方法.

关键词:

乙化乙化是一种循环素依赖的激酶酶.神经退行性疾病的神经退行性疾病转基因细胞分裂后的细胞分裂后翻译修改后的修改.在Ubiquitination中使用.

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