宿主和肠微生物组对荷尔斯坦牛的料效率特征的贡献
Guillermo Martinez Boggio1, Hugo F Monteiro2, Fabio S Lima2
1Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706.
Journal of dairy science
|December 22, 2023
概括
奶牛的料效率受到宿主遗传学和小肠微生物群的影响. 体微生物组介导宿主遗传效应,并对霍尔斯坦牛的料效率特征作出适度的贡献.
科学领域:
- 动物遗传学和动物基因组学
- 微生物组研究 微生物组研究
- 类动物营养 类动物营养
背景情况:
- 奶牛的表现是一个复杂的特征,受宿主基因组和小肠微生物群的影响.
- 遗传性 (h2),微生物性 (m2),直接遗传性 (h2d) 和全生物性 (ho2) 量化了遗传和微生物的贡献.
- 了解这些相互作用对于提高料效率至关重要.
研究的目的:
- 估计h2,h2d,m2和ho2对于干物摄入量,牛奶能量和剩余料摄入量.
- 评估结合基因组,微生物组及其相互作用的模型的预测能力.
- 调查肠微生物组在调解宿主基因对料效率影响中的作用.
主要方法:
- 利用了448头荷尔斯坦牛的料效率记录,SNP基因型数据和16S rRNA肠微生物丰度.
- 配备了三个内核模型:基因组 (G),基因组-微生物组 (GM) 和基因组-微生物组相互作用 (GMO).
- 使用相关性和偏差指标评估模型的适合性和预测能力.
主要成果:
- 整体生物模型 (GMO) 证明了最佳的适合性.
- 直接遗传性 (h2d) 比遗传性 (h2) 低10-15%,表明由微生物组介导的遗传效应.
- 微生物组的贡献 (m2) 是中等的,牛奶能量高达26%;全生物性 (ho2) 超过了h2d和m2的总和,突出显示了基因组对微生物组的相互作用.
结论:
- 乳头微生物组对哺乳期荷尔斯坦奶牛的料效率有中等但重要的贡献.
- 基因组对微生物组的相互作用在料效率方面发挥着重要作用.
- 纳入微生物组数据可以改善乳牛表现的预测模型,这表明微生物组介导的遗传效应.
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