一氧化碳在空气毒性综合征中的作用
G Hageman1, P van Broekhuizen2, J Nihom1
1Department of Neurology, Medisch Spectrum Twente, hospital Enschede, Koningsplein 1, 7500 KA Enschede, the Netherlands.
Neurotoxicology
|December 22, 2023
概括
飞机机空气中的一氧化碳 (CO) 导致了空气毒性综合征 (AS). 在近一半的航班中发现了高水平的二氧化碳,这对机组人员的健康构成风险,并可能损害其他毒素的排毒.
科学领域:
- 航空医学 航空医学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 空气毒性综合征 (AS) 与飞机机空气中有毒化合物的慢性低水平暴露有关,包括有机酸盐和挥发性碳化合物.
- 尽管一氧化碳存在于出血空气中,但一氧化碳 (CO) 在AS中的作用一直受到争论.
研究的目的:
- 评估有关一氧化碳 (CO) 导致飞机机空气中空气毒性综合征 (AS) 的证据.
- 评估机空气中的二氧化碳度,并将其与职业暴露限值进行比较.
主要方法:
- 一个系统的审查22个出版物涉及888个航班在18种飞机类型.
- 对机内二氧化碳度的分析分为低 (<5 ppm),中等 (5-10 ppm) 和高 (>10 ppm) 的水平.
- 包括报告烟雾事件,空气质量事件和诊断CO中毒的研究.
主要成果:
- 在42%的分析航班 (376/888) 中发现有毒CO水平 (>10 ppm),在14.5%的航班 (129/888) 中发现的水平在13-60 ppm之间.
- 高度的二氧化碳与在乘务员中诊断的二氧化碳中毒有关.
- 航空业的最大二氧化碳含量经常超过职业暴露限值.
结论:
- 一氧化碳 (CO) 是导致空气毒性综合征 (AS) 的有毒尾酒的一个重要因素.
- 建议将CO的职业暴露限值 (OEL) 降低到飞行员的5ppm (8小时TWA).
- 建议在机空气供应中进行持续的CO监测和探测器安装.
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