在周期性和静脉内内类固醇注射后发生的青光眼和眼睛高血压:基于索赔的分析
Ashley Polski1, Katy C Liu2, Divakar Gupta2
1Department of Ophthalmology, Moran Eye Center, Salt Lake City, Utah, USA ashley.polski@hsc.utah.edu.
BMJ open ophthalmology
|December 22, 2023
概括
眼部类固醇注射增加了患青光眼或眼部高血压 (OHT) 的风险. 接受重复注射或静脉内注射的患者需要密切监测类固醇诱导的玻璃眼.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼球类固醇注射通常用于各种眼睛疾病.
- 在使用类固醇后,出现二次性玻璃眼病的风险,包括开角玻璃眼病和眼睛高血压 (OHT) 是一个重大问题.
研究的目的:
- 为了确定在接受眼球类固醇注射后患开角眼光或OHT的发生率和风险.
- 为了确定特定的类固醇配方和与风险增加相关的管理途径.
主要方法:
- 从19,156名没有先前绿眼病史的成年患者中,对非识别的保险索赔数据 (IBM MarketScan数据库) 的回顾性分析.
- 纳入标准:2011年至2020年期间注射眼部类固醇.
- 使用Cox比例危险模型进行统计分析,以评估注射后5年内的风险.
主要成果:
- 20.5%的患者出现了新的青光眼/OHT,17.5%的患者开始了青光眼滴,2.27%的患者在5年内需要进行青光眼手术.
- 氨二醇下结膜注射的风险低于逆膜或内内注射 (HR 0.68).
- 素乙胺静脉内植入物 (0.59毫克) 的风险最高 (HR 2.01);多次注射显著增加了风险.
结论:
- 眼部类固醇注射可能会导致发展眼/OHT的风险,即使在没有病史的患者中也是如此.
- 在眼球类固醇注射后,密切监测患者至关重要,特别是在静脉内或重复注射时.
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