在中国农村的结核病患者中,宏观营养素摄入量与肝功能障碍之间的关联
Liangjie Zhao1,2, Mingxin Li1,2, Yue Li1,2
1Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.
Asia Pacific journal of clinical nutrition
|December 22, 2023
概括
充足的蛋白质和脂肪摄入量可以减少结核病患者的肝功能障碍. 碳水化合物摄入量显示出反向关联,蛋白质和脂肪观察到J形曲线,表明复杂的关系.
科学领域:
- 营养科学 营养科学
- 肝病学 肝病学是一种肝病学.
- 传染病研究传染病研究.
背景情况:
- 大量营养素显著影响肝脏健康和结核病 (TB) 的结果.
- 结核病患者中普遍存在不足的宏观营养素摄入量.
- 了解这些饮食关联对于改善结核病患者护理至关重要.
研究的目的:
- 研究结核病患者的宏观营养素摄入量 (蛋白质,脂肪,碳水化合物) 和能量百分比与肝功能障碍之间的关系.
- 使用限制立方线 (RCS) 探索剂量反应关系.
主要方法:
- 一项涉及2581名中国临成人结核病患者的横截面研究.
- 通过24小时回忆来评估饮食,以确定宏观营养素和能量摄入量.
- 肝功能障碍定义为ALT或AST>40U/L.
主要成果:
- 14.6%的结核病患者表现出肝功能障碍.
- 更高的蛋白质和脂肪摄入量,以及更高的脂肪转化为能量百分比,与减少肝脏功能障碍有关.
- 较低的碳水化合物能量百分比显示出类似的保护性关联.
- J型曲线表明蛋白质/脂肪摄入量与肝脏功能障碍之间的非线性关系.
结论:
- 特定的宏观营养素摄入模式与结核病患者的肝功能障碍患病率有关.
- 在子组中,线性关联是显著的:男性,正常的BMI和较低的能量摄入量 (<1636 kcal/d).
- 大量营养素摄入量与肝功能障碍之间的关系是复杂的,可能是非线性的.
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