在非常早产的婴儿中,提供早期和独家的肠道营养
Jacqueline Razzaghy1, Vivek V Shukla1, Emily Gunawan1
1Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Archives of disease in childhood. Fetal and neonatal edition
|December 22, 2023
概括
非常早产婴儿的早期和专用肠道营养显著增加了全养日和改善了生长. 这种养策略还降低了住院费用,使脆弱的新生儿受益.
科学领域:
- 新生儿营养和胃肠病学
- 围产儿医学 围产儿医学
- 儿科重症监护 儿科重症监护
背景情况:
- 最佳的营养对于非常早产的婴儿 (28-7-32周妊娠期) 来说至关重要.
- 正在研究早期和独家的肠道营养策略,以改善结果.
- 母乳和供体乳是新生儿养的关键来源.
研究的目的:
- 评估使用母乳或捐赠奶的早期和专属肠道营养的影响.
- 描述对非常早产婴儿的食进展,生长和住院治疗的影响.
主要方法:
- 在第三级新生儿重症监护病房中进行了一项并行组,无遮掩的随机对照试验.
- 102名非常早产的婴儿被随机分配给接受更高容量的早期肠道营养 (60-80毫升/公斤/天) 或标准的营养 (20-30毫升/公斤/天).
- 主要结局:28天内全口食日;次要结局:生长,身体组成和住院时间.
主要成果:
- 早期,独家肠道营养显著增加了+2天 (p=0.004) 的全肠道养日.
- 在随访期间,观察到改善的无脂肪体重对年龄z-score (+0.5,p=0.02) 和长度对年龄z-score (+0.6,p=0.002).
- 干预组的住院费用显著降低 (平均差异-28,754美元,p=0.04).
结论:
- 在非常早产的婴儿中,早期和独家的肠道营养增强了完全肠道养的实现.
- 这种养方法显示了改善无脂肪质量增加和线性生长的潜力.
- 该战略还可能导致医院住院费用的大幅降低.
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