在英格兰,青少年异常性关节炎的发病率和患病率在各族群之间存在差异
Richard P Beesley1, Kimme L Hyrich1,2, Jenny H Humphreys1,2
1Centre for Epidemiology Versus Arthritis, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Rheumatology (Oxford, England)
|December 22, 2023
概括
在英格兰,青少年异形性关节炎 (JIA) 的发病率在各族群之间有很大的差异. 白人儿童的JIA发病率高于混合,亚洲和黑人儿童,这表明疾病发生率存在差异.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 流行病学 流行病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 青少年异常性关节炎 (JIA) 是一种罕见的自身免疫性疾病,在16岁以下的儿童中引起慢性关节炎症.
- 准确的发病率和流行率数据对于了解JIA的社会影响和规划医疗保健服务至关重要.
- 缺乏以往国家对种族的估计.
研究的目的:
- 确定英格兰不同族群中JIA的发病率和流行率.
- 将JIA病例的种族分布与一般人口进行比较.
主要方法:
- 使用英格兰临床实践研究数据链接Aurum电子健康记录 (2003-2018).
- 使用医院情节统计数据验证的JIA病例.
- 采用了基平方测试来比较种族比例.
主要成果:
- 确定了424起事件JIA案件,其中389个被验证.
- 白人族群 (6.2/100,000) 的JIA发病率最高,混合族群 (3.0/100,000),亚裔 (2.7/100,000) 和黑人 (2.9/100,000) 的发病率较低.
- 关节性脑炎病例的种族分布与一般人口有显著差异 (P < 0.0001).
结论:
- 关节性脑炎的发病率和患病率在各族群之间显示出显著的差异.
- 观察到的差异可能源于遗传和社会经济因素.
- 进一步的研究对于有针对性的干预和公平的医疗保健提供至关重要.
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