持久的回声:感染后的先天免疫力的长期变化
Elisabeth A Dulfer1, Leo A B Joosten2, Mihai G Netea3
1Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.
训练有素的免疫力,免疫细胞的重编程,解释了长期的感染后症状. 这种免疫训练可以提供保护或导致有害的炎症和免疫.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 免疫系统对病原体的反应通常是急性和自我限制的.
- 长期的感染后症状可能会持续数月或数年.
- 训练免疫,涉及先天免疫细胞的表观遗传和代谢重编程,是理解这些长期影响的关键概念.
研究的目的:
- 审查传染病的适应性和不适应性后果.
- 探索训练有素免疫在长期感染后遗症中的作用.
- 讨论针对免疫失调的宿主导干预措施.
主要方法:
- 关于训练免疫和后传染性综合征的文献综述.
- 对先天免疫细胞内表观遗传和代谢重新连接的分析.
- 综合当前对感染后免疫失调的理解.
主要成果:
- 训练有素的免疫力可以增强对再感染的保护,但也会导致有害的结果.
- 由于训练有素的免疫系统引起的持续性炎症会导致组织损伤和心血管并发症.
- 抑制免疫功能或免疫可能是长期表观遗传变化的结果.
结论:
- 训练有素的免疫具有双重作用,提供保护或促进病理.
- 了解不同的训练免疫程序对于预测宿主结果至关重要.
- 定制宿主导干预措施对于管理长期免疫失调和推进治疗策略至关重要.
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