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相关概念视频

Immunological Memory01:23

Immunological Memory

624
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
624
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

4.0K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
4.0K
Stages of Infection01:26

Stages of Infection

56.5K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
56.5K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

991
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
991
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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相关实验视频

Updated: Jul 7, 2025

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
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持久的回声:感染后的先天免疫力的长期变化.

Elisabeth A Dulfer1, Leo A B Joosten2, Mihai G Netea3

  • 1Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.

European journal of internal medicine
|December 22, 2023
PubMed
概括

训练有素的免疫力,免疫细胞的重编程,解释了长期的感染后症状. 这种免疫训练可以提供保护或导致有害的炎症和免疫.

关键词:
传染性疾病 传染性疾病这是天生的免疫力.后感染性并发症 后感染性并发症训练有素的免疫力

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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
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相关实验视频

Last Updated: Jul 7, 2025

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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
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科学领域:

  • 免疫学 免疫学 免疫学
  • 传染性疾病 传染性疾病
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 免疫系统对病原体的反应通常是急性和自我限制的.
  • 长期的感染后症状可能会持续数月或数年.
  • 训练免疫,涉及先天免疫细胞的表观遗传和代谢重编程,是理解这些长期影响的关键概念.

研究的目的:

  • 审查传染病的适应性和不适应性后果.
  • 探索训练有素免疫在长期感染后遗症中的作用.
  • 讨论针对免疫失调的宿主导干预措施.

主要方法:

  • 关于训练免疫和后传染性综合征的文献综述.
  • 对先天免疫细胞内表观遗传和代谢重新连接的分析.
  • 综合当前对感染后免疫失调的理解.

主要成果:

  • 训练有素的免疫力可以增强对再感染的保护,但也会导致有害的结果.
  • 由于训练有素的免疫系统引起的持续性炎症会导致组织损伤和心血管并发症.
  • 抑制免疫功能或免疫可能是长期表观遗传变化的结果.

结论:

  • 训练有素的免疫具有双重作用,提供保护或促进病理.
  • 了解不同的训练免疫程序对于预测宿主结果至关重要.
  • 定制宿主导干预措施对于管理长期免疫失调和推进治疗策略至关重要.