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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

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Published on: March 21, 2018

预测和预防期内死产的情况.

Gordon C S Smith¹

¹Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK.

Seminars in perinatology

|December 22, 2023

概括

在期内死产是一种罕见但毁灭性的结果. 对母体血液的"奥米克"分析可以识别高风险怀孕的目标早期分娩,改善结果.

科学领域:

生殖医学生殖医学
基因组学就是基因组学.
围产期健康围产期健康

背景情况:

在高收入国家,死产影响了大约1000例终期怀孕中的1例.
母亲特征与死产风险有关,但大多数有风险的妇女在没有干预的情况下不会经历死产.
生死胎的原因往往是未知的,有多种贡献途径,如胎儿生长限制或过度生长.

研究的目的:

探索"omic"分析的潜力,以识别高风险死产的怀孕.
为查提供理由,以实现有针对性的早期分娩.

主要方法:

使用"omic"技术分析母亲的血液样本.
专注于识别与导致死产的疾病相关的生物标志物.

主要成果:

"奥米克"分析显示,在识别高风险死产的妇女方面,有前途.
有潜力区分可能受益于早产的怀孕.

结论:

通过"omic"查早期识别高风险怀孕是可行的.
针对性医疗指示的早产可以提供给最有可能受益的怀孕,可能降低死产率.

关键词:

生物标志物生物标志物怀孕怀孕怀孕怀孕查检查查检查查检查一个死胎,一个死胎.

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