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表皮SIRT6控制IL-17A的致病性,并驱动过敏气道炎症和重塑

Jingyun Quan1,2, Xiaoxia Wen3, Guomei Su3

  • 1Department of Respiratory and Critical Care Medicine, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523710, China.

Nature communications
|December 22, 2023
PubMed
概括

在严重的喘中,表皮性Sirtuin 6 (SIRT6) 在表观遗传上调节了Interleukin-17A (IL-17A). 抑制SIRT6可以减少气道炎症和重塑,这表明SIRT6是治疗点.

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