抗糖尿病药物与痴呆症之间的关联:基于日本药物不良事件报告数据库的研究
Yukiko Ishibashi1, Rintaro Sogawa2, Kenji Ogata1
1Department of Pharmacy, Saga University Hospital, 5-1-1, Nabeshima, Saga, 849-8501, Japan.
Clinical drug investigation
|December 22, 2023
概括
糖尿病似乎不会增加妄想风险. 然而,某些抗糖尿病药物,特别是硫尿素和胰岛素,可能与痴呆症的发展有关,需要进一步调查.
科学领域:
- 药物监督 药物监督 药物监督
- 临床药理学 临床药理学
- 老年医学 老年医学
背景情况:
- 在糖尿病和妄之间报告了不一致的关联.
- 关于抗糖尿病药物对妄风险的影响的证据有限.
研究的目的:
- 调查是否使用抗糖尿病药物是 Delirium 发作的风险因素.
- 分析糖尿病和妄想发病率之间的关系.
主要方法:
- 从日本不良事件报告数据库 (2004-2022) 中分析了662,899份报告.
- 报道几率比率 (ROR) 和狂妄症95%信心区间 (CI) 的计算.
- 针对潜在的混因素进行调整.
主要成果:
- 患有糖尿病和没有糖尿病的患者之间 Delirium 发病率没有显著差异 (1.37% vs 1.34%).
- 对硫氨酸urea (调整的ROR 1.75) 和胰岛素 (调整的ROR 1.35) 检测到的狂妄信号.
- 这些关联在经过调整以考虑混因素后仍然显著.
结论:
- 糖尿病并没有与 Delirium 的风险增加有关.
- 硫尿素和胰岛素的使用可能与痴呆症的发展有关.
- 需要进一步的研究来验证这些发现.
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