血小板计数和早产严重视网膜病变的风险:贝叶斯模型平均元分析
Mohamad F Almutairi1, Silvia Gulden2, Tamara M Hundscheid1
1Division of Neonatology, Department of Pediatrics, MosaKids Children's Hospital, Maastricht University Medical Center (MUMC+), School for Oncology and Reproduction (GROW), Maastricht University, 6202 AZ Maastricht, The Netherlands.
Children (Basel, Switzerland)
|December 23, 2023
概括
低血小板计数,特别是血小板缺血,与早产严重视网膜病变 (ROP) 有关. 这种关联在ROP治疗期间最强烈,尽管出版偏见缓和了证据.
科学领域:
- 新生儿医学 新生儿医学
- 血液学 血液学 血液学
- 眼科医生 眼科 眼科
背景情况:
- 早产视网膜病变 (ROP) 是早产婴儿视力损伤的重要原因之一.
- 血小板计数和血小板缺血被认为是严重ROP的潜在生物标志物.
研究的目的:
- 系统地审查和元分析血小板计数和严重的ROP之间的关联.
- 评估血小板缺血作为严重ROP的风险因素的证据.
主要方法:
- 21项研究的系统综述和贝叶斯模型平均元分析 (BMA).
- 在第一阶段 (<2周) 和第二阶段 (围绕ROP治疗) 的血小板计数分析.
- 贝叶斯因子 (BFs) 的计算,以量化证据的强度.
主要成果:
- 在两个阶段,BMA表明了低血小板计数和严重的ROP之间的关联.
- 对于第一阶段有强有力的证据 (BF10=13.5),对于第二阶段有非常强有力的证据 (BF10=51.0).
- 第2阶段的血小板缺血显示出非常强烈的关联 (BF10 = 28.2),在调整出版偏差后,持续存在中度证据 (BF10 = 4.30).
结论:
- 血栓缩与早产的严重视网膜病变有关.
- 支持这种关联的证据被出版偏见所抑制.
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