将血液对高压氧气的反应与高强度间歇训练的反应进行比较 - - 一项针对健康志愿者的交叉研究
Anders Kjellberg1,2, Maléne E Lindholm1,3, Xiaowei Zheng4
1Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
Antioxidants (Basel, Switzerland)
|December 23, 2023
概括
高强度间歇训练 (HIIT) 和高压氧疗法 (HBOT) 对免疫细胞产生类似的影响,影响与炎症和缺氧相关的通路中的基因表达. 需要进一步的研究来将这些变化与治疗剂量和个体反应相关联.
科学领域:
- 免疫学 免疫学 免疫学
- 运动生理学 运动生理学
- 氧气疗法是一种氧气疗法.
背景情况:
- 众所周知,高强度间歇训练 (HIIT) 和高压氧疗法 (HBOT) 诱导反应性氧物种 (ROS) 并调节免疫反应.
- 由于缺乏生物标志物来评估剂量反应关系,HBOT的临床应用受到阻碍.
研究的目的:
- 研究监测免疫细胞对HBOT和HIIT反应的可行性.
- 为了比较一个简短的HBOT会话与一个HIIT会话对免疫细胞的影响.
- 探索血液中的潜在生物标志物和用于跟踪个体反应的PBMC.
主要方法:
- 十名健康的志愿者接受了一项交叉研究,包括28分钟的HIIT和28分钟的HBOT.
- 通过大量RNA测序 (mRNA和microRNA) 分析了外周血液单核细胞 (PBMC).
- 在周围静脉血液中测量了血液气体,周围静脉氧和度 (SpvO2) 和ROS水平.
主要成果:
- 在HIIT和HBOT之间观察到基因表达变化 (166个基因) 的显著重叠,主要是在缺氧和炎症途径中.
- 这两种干预都导致NF-κB信号基因的下调和干扰素信号基因的上调.
- 虽然HIIT提高了ROS水平,但HBOT在本研究中没有显示ROS的显著变化.
结论:
- 高压氧气疗法诱导PBMCs可测量的基因表达变化,类似于HIIT.
- 鉴定的基因表达变化为HBOT效应提供了潜在的生物标志物.
- 需要进一步调查,以确定这些分子变化,治疗剂量和个体患者反应之间的相关性.
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