查尔森-迪奥并发症指数作为一种新型预测器,用于非肌肉侵入性膀癌的复发
Lukas Scheipner1, Hanna Zurl1, Julia V Altziebler1
1Department of Urology, Medical University of Graz, 8010 Graz, Austria.
Cancers
|December 23, 2023
概括
通过查尔森-戴约并发症指数 (CCI) 测量较高的并发症负担,与非肌肉侵入性膀癌 (NMIBC) 复发的风险增加有关. 患有更多并发症的患者需要更紧密地遵守随访协议.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 复发是一个重大的临床挑战.
- 患者的并发症可以影响癌症的结果和治疗坚持.
- 查尔森-迪约并发症指数 (CCI) 是一种广泛使用的健康状况衡量指标.
研究的目的:
- 调查查尔森-戴约并发症指数 (CCI) 与非肌肉侵入性膀癌 (NMIBC) 患者复发风险之间的关联.
主要方法:
- 在2010年至2018年期间接受治疗的1072名NMIBC患者的回顾性分析.
- 利用Kaplan-Meier估计和Cox回归模型来评估基于CCI的复发风险.
- 并发症负担被分类为低 (CCI ≤4) 与高 (CCI >4) 以及连续变量.
主要成果:
- 患有高并发症负担 (CCI>4) 的患者显示NMIBC复发的风险明显更高.
- 多变量分析证实,高的CCI独立预测了复发风险的增加 (HR 1.42,p=0.018).
- 每增加1个单位的CCI都与5%的复发风险增加有关 (HR1.05,p=0.04).
结论:
- 伴随性疾病在NMIBC患者中很普遍,并且与较差的治疗结果有关.
- 较高的CCI得分与膀癌复发的风险增加有关.
- 具有高并发症负担的NMIBC患者需要加强遵守监测和后续指南.
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