定义异常老年评估:哪些缺陷最重要?
Anthony Carrozzi1,2, Rana Jin3, Susie Monginot3
1Department of Medicine, Toronto General Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Cancers
|December 23, 2023
概括
定义异常老年评估 (GA) 在老年瘤学中至关重要. 异常的GA,特别是认知问题,并发症和跌倒风险,与治疗计划的修改有关.
科学领域:
- 老年瘤学 老年瘤学
- 临床评估 临床评估
- 治疗计划 治疗计划
背景情况:
- 老年人的评估 (GA) 在老年人瘤学中至关重要,但缺乏"异常"的明确定义.
- 异常GA域与治疗计划修改 (TPM) 之间的关联需要进一步调查.
- 确定可预测TPM的关键GA域对于优化老年人癌症护理至关重要.
研究的目的:
- 在老年瘤学中定义什么是异常老年评估.
- 确定特定的老年医学评估领域与治疗计划修改之间的关联.
- 确定异常域的最佳数值值,以预测治疗计划的修改.
主要方法:
- 对老年瘤诊所数据库的回顾性审查 (2015年5月 - 2022年6月).
- 后勤回归建模用于评估GA域/值与TPM之间的关联.
- 对736名接受治疗决策的新患者的分析.
主要成果:
- 预测TPM的异常GA域的最佳不变值为4 (AUC0.628).
- 包括认知,并发症和跌倒风险在内的多变量模型显示出最高的预测准确度 (AUC 0.704).
- 在多变量模型中,4个异常域的值产生了0.689.68的AUC.
结论:
- 在瘤学中,异常老年评估最好通过认知异常,并发病症和跌倒风险来定义.
- 预测治疗计划修改的最佳数值值是4个异常域.
- 这些发现可以完善异常GA的定义,并改善老年癌症患者的治疗决策.
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