目前的恶性肺半径瘤的最新治疗方法和以免疫疗法为中心的未来选择
Susana Cedres1, Augusto Valdivia1, Patricia Iranzo1
1Medical Oncology Department, Vall d´Hebron Institute of Oncology (VHIO), Vall d'Hebron Hospital Universitari, 08035 Barcelona, Spain.
Cancers
|December 23, 2023
概括
结合nivolumab和ipilimumab的免疫疗法是恶性多发性间皮瘤 (MPM) 的新标准,改善了整体存活率. 目前正在进行研究,以确定生物标志物,以便更好地选择患者接受免疫疗法治疗.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 生物标志物 生物标志物
背景情况:
- 恶性多层层层瘤 (MPM) 是一种与石棉有关的侵袭性癌症.
- 标准治疗包括基于的化疗,而贝瓦齐祖马布提供了适度的生存益处.
- 最近的免疫疗法 (nivolumab/ipilimumab) 在一线MPM治疗中显示出更高的整体存活率.
研究的目的:
- 审查目前 (2023) 的MPM治疗策略,重点是免疫疗法.
- 在MPM中评估一线和随后免疫治疗的疗效.
- 确定潜在的生物标志物来预测免疫疗法反应.
主要方法:
- 对MPM免疫疗法研究的文献综述.
- 对临床试验数据的分析 (例如,CheckMate-743).
- 探索包括PD-L1,组织学,淋巴细胞群和瘤突变负担 (TMB) 在内的生物标志物.
主要成果:
- 与MPM的化疗相比,尼沃卢马布/伊皮利穆马布组合显示出更高的整体存活率.
- 免疫疗法代表了一种新的护理标准,得到了FDA和EMA的批准.
- 在MPM中,生物标志物对免疫治疗反应的预测价值仍在调查中.
结论:
- 免疫疗法为MPM患者提供了显著的生存优势.
- 需要进一步的研究来确定可靠的生物标志物用于患者选择.
- 优化免疫疗法使用需要了解MPM的预测标记.
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