运动在与癌症相关的缩症和缩性肥胖症中的作用
Argyro Papadopetraki1, Antonios Giannopoulos2,3, Maria Maridaki4
1Department of Physiology, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Cancers
|December 23, 2023
概括
运动通过调节蛋白质合成,炎症和HPA轴来对抗与癌症相关的肌肉消耗 (sarcopenia) 和sarcopenic肥胖症. 运动也可以改善患者的生活质量.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 标志着肌肉消耗和力量丧失的萨尔科佩尼亚是癌症及其治疗的常见副作用.
- 与癌症相关的sarcopenic肥胖症涉及肌肉损失与脂肪质量增加相结合,这两者都会影响疾病的进展和生存.
- 身体炼被公认为瘤患者的安全有效的补充疗法.
研究的目的:
- 审查通过运动来管理与癌症相关的瘤症和瘤性肥胖症的病理生理机制.
- 讨论运动在调节关键生物通路中的作用,包括蛋白质合成,线粒体功能,炎症反应和下丘脑-垂体-上腺 (HPA) 轴.
- 要突出肌肉运动释放的肌基因在调解运动的益处中的作用.
主要方法:
- 现有文献的叙述性审查.
- 对运动影响的病理生理机制的分析.
- 讨论肌基因在运动对肌肉平衡的影响中的作用.
主要成果:
- 运动干预可以限制肌肉代谢,并促进癌症患者的肌肉质量维护.
- 运动可以抵消肌肉质量损失,并改善临床结果和生活质量,即使在肉类开始后.
- 运动调节蛋白质合成,线粒体功能,炎症和HPA轴,有助于治疗肉症.
结论:
- 身体炼是管理与癌症相关的瘤症和瘤性肥胖症的关键治疗策略.
- 运动干预措施通过改善肌肉平衡和患者的生活质量提供了显著的好处.
- 肌基因是运动对癌症患者肌肉健康有益影响的关键媒介.
相关概念视频
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:27Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
01:20Exercise and Cardiovascular Response
820
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
820
01:17Exercise and Cardiac Output
1.0K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.0K
01:24Obesity
507
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
507