Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Fibril-associated Collagen01:11

Fibril-associated Collagen

2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

4.3K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
4.3K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

2.2K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
2.2K
Structural Protein Function01:56

Structural Protein Function

27.7K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
27.7K
Glycosaminoglycans01:23

Glycosaminoglycans

4.9K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.9K
Hydration of Cement01:24

Hydration of Cement

238
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
238

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>In silico</i> cooling rate dependent crystallization and glass transition in <i>n</i>-alkanes.

Physical chemistry chemical physics : PCCP·2025
Same author

Multi-proton dynamics near membrane-water interface.

Nature communications·2025
Same author

Lateral diffusion of ions near membrane surface.

Physical chemistry chemical physics : PCCP·2024
Same author

Temperature and Nuclear Quantum Effects on the Stretching Modes of the Water Hexamer.

The journal of physical chemistry. A·2020
Same author

Temperature Dependence of Intramolecular Vibrational Bands in Small Water Clusters.

The journal of physical chemistry. B·2019
Same author

Isoelectronic Theory for Cationic Radii.

Journal of the American Chemical Society·2017
Same journal

Correction: Reis et al. Bioinks Enriched with ECM Components Obtained by Supercritical Extraction. <i>Biomolecules</i> 2022, <i>12</i>, 394.

Biomolecules·2026
Same journal

Correction: Kim, K.-H.; Yoo, B.C. Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. <i>Biomolecules</i> 2026, <i>16</i>, 465.

Biomolecules·2026
Same journal

Correction: Bastyte et al. The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy. <i>Biomolecules</i> 2024, <i>14</i>, 212.

Biomolecules·2026
Same journal

AtHSPR Plays a Positive Role in Arabidopsis Resistance Against <i>Pseudomonas syringae</i> pv. <i>tomato</i> DC3000 by Interacting with TOP1.

Biomolecules·2026
Same journal

CYTH4 Facilitates Renal Cell Carcinoma via Enhancing Proliferation and Likely Immune Evasion.

Biomolecules·2026
Same journal

Integrated Immune-Gut Profiling Identifies an Exploratory Pediatric Inflammatory Intestinal Profile Associated with Food-Specific IgG Reactivity.

Biomolecules·2026
查看所有相关文章

相关实验视频

Updated: Jul 7, 2025

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

413

原蛋白结构化水解

Satyaranjan Biswal1, Noam Agmon1

  • 1The Fritz Haber Research Center, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.

Biomolecules
|December 23, 2023
PubMed
概括
此摘要是机器生成的。

原蛋白的刚性来自于有序的水化层. 分子动力学模拟揭示了水分子在原仿真周围的独特排列,即使在液相中也保持稳定.

关键词:
这就是SASASA.原蛋白是一种原蛋白.补充水分 补充水分 补充水分在这种情况下,它会产生键.旋转半径的旋转半径居住时间 居住时间水水水的水水的水

更多相关视频

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
07:12

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

2.3K
In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
07:54

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

13.8K

相关实验视频

Last Updated: Jul 7, 2025

Production of Nanofibrillar Patterned Collagen for Tissue Engineering
07:34

Production of Nanofibrillar Patterned Collagen for Tissue Engineering

Published on: September 20, 2024

413
Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment
07:12

Microengineering 3D Collagen Hydrogels with Long-Range Fiber Alignment

Published on: September 7, 2022

2.3K
In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
07:54

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

13.8K

科学领域:

  • 生物物理学的生物物理.
  • 结构生物学 结构生物学
  • 材料科学 材料科学 材料科学

背景情况:

  • 原蛋白是一种三螺旋蛋白,为骨和肌等连接组织提供必要的刚性和稳定性.
  • 了解原蛋白机械性质的分子基础对于组织工程和生物材料开发至关重要.

研究的目的:

  • 为了研究水分子在室温下对原仿真的水化作用的结构组织.
  • 阐明第一个水化层中体结构和水结合模式之间的关系.

主要方法:

  • 用分子动力学模拟来研究[(PPG) [10]3原仿真.
  • 分析包括旋转半径,溶剂可访问的表面积 (SASA) 和脊柱碳基 (bb-CO) 位点的水占用.

主要成果:

  • 模拟揭示了水分子与bb-CO氧原子结合的显著有序的第一水合层.
  • 在液态阶段的PPG三胞胎中观察到水占用率 (0-1.7-1) 的重复规律,类似于晶体数据.
  • 尽管水的交换率很快,bb-CO场地仍然保持着稳定的占用,保持结构秩序.

结论:

  • 订购的第一个水化外对原仿真的刚性和稳定性做出了重大贡献.
  • 这种水组织保持在液态阶段,突出其强度.
  • 未来的研究将探索由此产生的圆柱状静电潜力在周围.