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Updated: Jul 7, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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在衰老和神经退行性疾病中通过线粒体未折叠蛋白反应 (mtUPR) 进行线粒体质量控制

Paula Cilleros-Holgado1, David Gómez-Fernández1, Rocío Piñero-Pérez1

  • 1Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), 41013 Sevilla, Spain.

Biomolecules
|December 23, 2023
PubMed
概括

线粒体展开蛋白质反应 (mtUPR) 通过控制线粒体内的蛋白质折叠,对细胞健康至关重要. 激活mtUPR可以通过减少神经元损伤来治疗神经退行性疾病.

关键词:
年龄化的衰老.线粒体中的线粒体.线粒体生物发生是线粒体生物发生.线粒体疾病是线粒体疾病.线粒体的动力学线粒体质量控制机制线粒体展开的蛋白质反应 (mtUPR)线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.神经退行性疾病的神经退行性疾病治疗目标是治疗的目标.

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