凝结酶阴性葡萄球菌作为绵羊乳腺炎的病因因因子,重点关注亚临床形式
Marios Lysitsas1, Vassiliki Spyrou2, Charalambos Billinis1
1Faculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece.
Antibiotics (Basel, Switzerland)
|December 23, 2023
概括
凝聚酶阴性葡萄球菌 (CoNS) 在绵羊乳腺炎中很常见,特别是在亚临床病例中. 研究表明,亚洲和南美地区的抗菌素耐药性更高,其中Staphylococcus epidermidis是最常见的物种.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物健康 动物健康
- 细菌学 细菌学是一门学科.
背景情况:
- 凝聚酶阴性葡萄球菌 (CoNS) 是绵羊乳腺炎的重要病原体.
- 亚临床的绵羊乳腺炎带来了诊断上的挑战.
- 了解CoNS的分布和特征对于有效管理至关重要.
研究的目的:
- 审查Cons在绵羊乳腺炎中的全球分布和特征.
- 分析抗生素耐药性模式和遗传因素 (生物膜,毒素).
- 评估用于在绵羊乳腺炎中识别CoNS的诊断方法.
主要方法:
- 按照PRISMA指南进行系统的文献审查.
- 包括过去20年发表的139项研究.
- 提取有关地理分布,细菌物种,抗生素耐药性和遗传特征的数据.
主要成果:
- 欧洲和南美是CONS对绵羊乳腺炎研究的领先地区.
- 斯塔菲洛科克斯表皮球菌是最常见的CoNS物种 (约39%).
- 观察到对青素 (32.8%) 和阿莫西西林 (32.1%) 的耐药性高,亚洲和南美洲的耐药性更高.
结论:
- 在全球范围内,CoNS,特别是S. epidermidis在绵羊乳腺炎中很普遍.
- 抗菌素耐药性是一个日益关注的问题,特别是在亚洲和南美地区.
- 建议在未来的研究中采用分子鉴定方法,以更好地了解羊乳腺炎中的CoNS.
相关概念视频
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...