抗生素增强作为一种有前途的策略,用于打击细菌病原体中的宏类耐药性
Deepjyoti Paul1, Meenal Chawla1, Taruna Ahrodia1
1Functional Genomics Laboratory, Translational Health Science and Technology Institute (THSTI), NCR Biotech Science Cluster, Faridabad 121001, India.
Antibiotics (Basel, Switzerland)
|December 23, 2023
概括
抗生素耐药性是一个日益增长的威胁. 本综述探讨了抗生素增强剂,即增强现有抗生素的化合物,以对抗巨化物耐药性并恢复它们对抗耐药细菌的有效性.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 抗生素彻底改变了医学,但广泛的耐药性现在威胁着现代医疗保健.
- COVID-19大流行加速了宏类抗生素的使用,导致宏类耐药性增加.
- 对于应对抗微生物药物耐药性 (AMR) 的替代策略存在关键需求.
研究的目的:
- 审查细菌对宏类抗生素的耐药性机制.
- 识别和强调增强宏类抗生素作用的关键化合物.
- 探索抗生素增强剂在逆转宏类耐药性的潜力.
主要方法:
- 对宏类抗药机制研究的文献综述.
- 对天然和合成化合物作为抗生素增强剂的研究进行分析.
- 综合了关于增强宏类抗多药耐药 (MDR) 病原体功效的化合物的发现.
主要成果:
- 细菌已经进化出了各种机制来抵抗宏化物.
- 许多天然和合成化合物在增强宏化物方面表现有前途.
- 这些增强剂可以恢复或增强现有的类抗生素的活性.
结论:
- 抗生素增强剂提供了一种可行的策略来对抗AMR.
- 鉴于缺乏新药开发,恢复当前抗生素的疗效至关重要.
- 对宏类强化剂的进一步研究可能会为MDR感染提供新的治疗选择.
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