微封装的甲酸盐缓解了通过肠道微生物群引起的免疫损伤和肠道问题,这些问题是由Clostridium Perfringens引起的
Ting Yang1, Yaowei Sun1, Zhenglie Dai1
1College of Animal Science and Technology, College of Veterinary Medicine, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, Zhejiang Agricultural and Forestry University, Hangzhou 311300, China.
微封装的甲酸盐 (MS-SB) 增强肉的免疫力和肠道健康,对抗Clostridium perfringens. MS-SB改善了肠道形态,免疫反应和肠道微生物群,表现优于标准的酸盐 (SB).
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 动物营养 动物营养
- 免疫学 免疫学 免疫学
背景情况:
- 菌 (C. perfringens) 感染对肉的健康和生产力构成重大威胁.
- 酸盐 (SB) 是一种有益的料添加剂,但其有效性可能因在上部胃肠道中过早释放而受到限制.
- 微封装SB (MS-SB) 提供了一种策略,以改善在肠道中SB的向输送和持续释放.
研究的目的:
- 为了评估MS-SB对C. perfringens的保护作用,我们在 brojlers中提出了挑战.
- 阐明MS-SB的保护作用的基本机制,包括其对免疫状态,肠道形态,挥发性脂肪酸 (VFA) 生产和肠道微生物群的影响.
- 为了比较MS-SB与传统SB补充剂的疗效.
主要方法:
- 肉补充了SB或MS-SB,持续56天.
- 随后,鸟类被C. perfringens三次挑战,以诱导感染.
- 测量包括胸腺指数,血清免疫参数 (IgA,IgY,IgM),促炎性细胞因子 (IL-1β,IL-6,TNF-α),肠的高度和密室深度,VFA度和肠微生物群组成.
主要成果:
- 两种MS-SB和SB补充剂都显著调节了免疫反应,增加了有益的抗体,并减少了促炎性细胞因子.
- MS-SB显示出比SB更高的疗效,显示出更高的IgA水平和更低的IL-1β度.
- 补充MS-SB或SB改善了肠道的高度和的高度/密室深度比,增强了VFA生产 (特别是异酸和酸),并积极调节了菌群组成,增加了诸如Bacteroides和Faecalibacterium之类的有益细菌.
结论:
- 饮食MS-SB和SB补充剂可以增强肉的免疫状态,肠道形态和VFA生产,同时调节肠道微生物群对C. perfringens的反应.
- 在相当的补充水平上,MS-SB比SB更有效,为肉提供了更好的保护和肠道健康益处.
- 在家禽生产中,MS-SB是减轻C. perfringens感染对家禽生产的负面影响的有希望的战略.
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