基于功能子网络的增强动态横向性,用于双极性障碍患者
Dandan Li1, Jiangping Hao1, Jianchao Hao1
1College of Computer Science and Technology, Taiyuan University of Technology, Jinzhong 030600, China.
Brain sciences
|December 23, 2023
概括
双极性障碍 (BD) 患者表现出大脑侧面性的改变,特别是在注意力网络中. 大脑横向化的动态变化为BD神经病理学提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 异常的大脑横向性经常在双相情感障碍 (BD) 中观察到.
- 了解改变的大脑横向化对于探索BD病变的产生至关重要.
- 在BD中大脑横向化的动态变化仍未得到充分研究.
研究的目的:
- 与正常对照组 (NC) 相比,研究双相情感障碍 (BD) 患者大脑横向性的动态变化.
- 通过分析动态大脑横向化,为BD神经病理学提供新的见解.
主要方法:
- 利用了48名BD患者和48名NC患者的功能磁共振成像 (fMRI) 数据.
- 在滑动窗口上提取动态横向性索引 (DLI),以创建动态横向性时间序列.
- 采用k-means集群和Arenas-Fernandez-Gomez (AFG) 算法来识别横向状态.
主要成果:
- 与NC相比,BD患者在右半球的注意网络 (AN) 中在所有窗口和状态1中显示出更高的平均横向性指数 (MLI).
- 左半球的AN在BD患者中表现出更频繁的横向性波动.
- 在状态1期间右半球AN中较高的MLI与BD症状严重程度有关.
结论:
- 动态大脑横向性分析揭示了BD患者的独特模式.
- 注意网络中的侧面性变化是BD神经病理学的关键特征.
- 这些发现有助于更深入地了解BD潜在的大脑机制.
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