中度低氧的神经保护作用:系统性审查
Viktoria Damgaard1,2, Johanna Mariegaard1,2, Julie Marie Lindhardsen1,2
1Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Copenhagen Affective Disorder Research Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Hovedvejen 17, DK-2000 Frederiksberg, Denmark.
Brain sciences
|December 23, 2023
概括
中度缺氧对大脑疾病有很大的前景,大多数人体研究报告认知益处. 然而,方法上的缺陷需要更大,更强大的试验来确认有效性和安全性.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 医学研究 医学研究
背景情况:
- 新兴证据表明,中度缺氧 (10-16% O2) 是各种脑部疾病的潜在治疗策略.
- 了解缺氧的神经生物学机制和临床影响对于开发有效治疗非常重要.
研究的目的:
- 系统地审查人类和动物对脑疾病缺氧的研究,评估研究结果和方法质量.
- 为未来的研究和临床应用确定最佳的治疗方案.
主要方法:
- 根据PRISMA 2020指南进行系统审查,搜索主要数据库 (PubMed,PsycInfo,EMBASE,Cochrane图书馆).
- 使用偏差风险工具对8项人类研究 (N=274) 和48项动物研究进行了独立审查.
- 分析对认知,运动功能,神经成像和分子标记物的影响.
主要成果:
- 75%的人类研究报告了缺氧对认知和/或神经学的益处.
- 所有的人类研究都显示出因缺乏随机化和盲目的偏差而存在高风险.
- 低剂量,间歇性缺氧 (30-240分钟),特别是与训练一起,显示出好处;高剂量,慢性缺氧导致不良反应.
结论:
- 中度缺氧表明对大脑疾病的潜在治疗益处,特别是在优化剂量和持续时间的情况下.
- 目前人类研究的重大方法限制阻碍了最终的结论.
- 较大的,在方法上强大的翻译研究对于验证缺氧作为安全有效的脑疾病治疗方法至关重要.
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