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在后急性COVID-19综合征中,皮层GABA水平降低

Ksenija Marinkovic^1,2, David R White¹, Austin Alderson Myers^1,3

¹Spatio-Temporal Brain Imaging Lab, Department of Psychology, San Diego State University, San Diego, CA 92182, USA.

|December 23, 2023

概括

长期COVID患者表现出较低的大脑GABA水平,与抑郁和认知问题有关. 这表明皮层过度兴奋可能是COVID-19后急性后续症状中持续的神经认知功能障碍的基础.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
精神病学是一个精神病学.

背景情况:

后急性COVID-19 (PASC) 或长期COVID的后续影响感染后的许多人.
PASC通常涉及认知功能障碍和情绪障碍,神经机制不清楚.
患有PASC的年轻,以前健康的成年人报告记忆/注意力缺陷和疲劳.

研究的目的:

使用质子磁共振光谱 (1H-MRS) 调查长期COVID中的神经化学变化.
在PASC中检查GABA水平,认知功能和情感困扰之间的关系.
探索潜在的神经机制,包括皮质刺激/抑制平衡.

主要方法:

招募了PASC的年轻人 (平均持续时间~6个月) 和匹配的对照 (CNT).
使用1H-MRS测量脑后皮层GABA+/水和N-乙酸 (NAA).
进行相关性和调解分析,将神经化学与临床症状联系起来.

主要成果:

与CNT相比,PASC组表现出明显较低的GABA+/水,与抑郁症和睡眠不佳相关.
较低的GABA+/水部分介导了PASC对抑郁症的影响,表明皮层过度兴奋.
在PASC组中,较低NAA的趋势表明神经元完整性可能受到损害.

结论:

在PASC中皮质GABA水平降低可能会通过过度兴奋性导致抑郁和认知缺陷.
神经元完整性受损也可能在长期COVID神经认知功能障碍中发挥作用.
神经炎症是PASC病变发生的潜在因素.

关键词:

1H-MRS的时间.对于GABA来说,这是一个很好的选择.这就是NAA NAA.焦虑是一种焦虑.认知缺陷认知缺陷抑郁抑郁症抑郁症抑郁症抑郁症激发/抑制平衡的平衡.失眠是因为失眠.长时间的COVID.磁共振光谱学磁共振光谱学

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