基于青少年酒精使用史的脑网络拓学的差异
Haley A Kirse1,2, Mohsen Bahrami1,3, Robert G Lyday1,3
1Laboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA.
Brain sciences
|December 23, 2023
概括
青少年饮酒会改变大脑网络的组织. 危险饮酒者与没有/低酒精使用者相比,显示出不同的大脑连接模式,这表明潜在的长期发育损害.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 成研究 研究成研究
背景情况:
- 青少年饮酒影响着数百万年轻人.
- 虽然研究了行为效应,但大脑功能变化仍然不清楚.
- 酒精对青少年大脑发育的影响需要进一步调查.
研究的目的:
- 调查与饮酒相关的青少年大脑连接的差异.
- 为了确定酒精使用如何影响青少年的大脑网络拓.
主要方法:
- 利用了来自全国青少年酒精和神经发育联盟 (NCANDA) 的休息状态功能磁共振成像 (fMRI) 数据.
- 从698名年轻人 (12-21岁) 构建了大脑网络,将117名危险饮酒者与581名无/低饮酒者进行比较.
- 在八个预定义网络和全脑连接中评估大脑网络拓学的差异.
主要成果:
- 没有/低饮酒者在像中央行政网络 (CEN) 这样的网络中表现出更强的全球效率和更少的集群连接.
- 危险饮酒者表现出相反的模式,全球效率较弱,某些网络中的连接更集群.
- 在青少年饮酒组之间观察到大脑网络的显著组织差异.
结论:
- 青少年的酒精使用与明显的脑网络组织差异有关.
- 异常的大脑连接模式可能与年轻人的危险饮酒行为有关.
- 研究结果表明,青少年饮酒的潜在长期神经发育后果.
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