在患有严重形式的COVID-19患者中,抗脂抗体和血管血栓症
Mirjana Zlatković-Švenda1,2,3, Milica Ovuka4,5, Manca Ogrič6
1Institute of Rheumatology Belgrade, 11000 Belgrade, Serbia.
Biomedicines
|December 23, 2023
概括
在严重的COVID-19中,抗脂抗体 (aPLA) 通常是短暂的,与血栓形成或致命结果无关. 患有COVID-19和aPLA的患者可以遵循标准抗凝剂方案.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 抗脂抗体 (aPLA) 是诊断抗脂综合征 (APS) 的关键.
- aPLA与血栓形成和产科并发症有关.
- 在严重的COVID-19血栓栓塞栓症中APLA的作用需要调查.
研究的目的:
- 调查aPLA与住院COVID-19肺炎患者的临床结果之间的关联.
- 在住院和随访期间在多个时间点分析aPLA水平.
主要方法:
- 评估了9种类型的aPLA (IgM,IgG,IgA),包括抗心脂蛋白,抗β2-糖蛋白I,以及抗脂胺/抗胺.
- 在111名COVID-19患者中收集了有关血栓形成和妊娠并发症的临床数据.
- 在入院时监测PLA,恶化,出院和3个月的随访.
主要成果:
- 在aPLA阳性患者中,肺动脉血栓栓塞并未导致死亡.
- 只有一个有静脉血栓形成史的患者是aPLA阳性,被诊断为APS.
- 在有血栓形成史 (55.6%) 和没有血栓形成史 (26.1%) 的患者中,在出院时过渡性aPLA阳性更为常见.
结论:
- 在严重的COVID-19中,aPLA阳性通常是短暂的,而不是血栓形成或死亡的重要预测因素.
- 建议在COVID-19患者中使用标准抗凝剂治疗,无论有或没有aPLA.
- 进一步的研究可能会澄清持续性aPLA在COVID-19相关的凝血病中的特定作用.
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