在癌症免疫治疗中准CD24
Wenwen Chen1, Zhigang Hu1, Zhigang Guo1
1Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China.
Biomedicines
|December 23, 2023
概括
分化集群24 (CD24) 是一种关键的癌症抗原. 针对CD24的疗法,包括单克隆抗体和CAR T细胞疗法,正在成为有前途的癌症治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 免疫疗法是一种关键的癌症治疗方式.
- 识别瘤抗原是有效的癌症免疫治疗的关键.
- 分化24集群 (CD24) 是一种高度表达的瘤相关抗原,在各种癌症中具有高度表达.
研究的目的:
- 审查目前和未来针对CD24的治疗策略.
- 突出CD24作为瘤抗原在癌症进展中的作用.
主要方法:
- 关于CD24作为癌症点的研究文献综述.
- 现有治疗方法的总结,包括单克隆抗体,抗体-药物合物 (ADC),仿真抗原受体 (CAR) T细胞疗法和CAR-NK细胞疗法.
- 对CD24参与与癌症相关的信号通路和免疫相互作用的分析.
主要成果:
- CD24在各种瘤类型中经常过度表达.
- CD24通过与信号通路和免疫细胞的相互作用影响瘤的进展.
- 针对CD24的多种治疗方式正在研究和开发中.
结论:
- CD24代表了新型癌症免疫疗法的一个有希望的目标.
- 对CD24向治疗的进一步研究可能会导致改善癌症治疗结果.
- 涉及CD24向剂的组合策略可能会提高治疗疗效.
相关概念视频
01:27Tumor Immunotherapy
529
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
529
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K