在2型糖尿病男性的丸激素治疗期间减少肝素:一个随机,双盲,安慰剂控制的随机研究
Line Velling Magnussen1, Louise Helskov Jørgensen2, Dorte Glintborg1
1Department of Endocrinology and Metabolism, Odense University Hospital, 5000 Odense, Denmark.
Biomedicines
|December 23, 2023
概括
替代疗法 (TRT) 降低了2型糖尿病男性的肝素水平. 这种减少表明TRT具有直接的抗炎作用,独立于铁或身体组成的变化.
科学领域:
- 内分泌学 在内分泌学.
- 心血管疾病研究研究
- 炎症研究 炎症研究
背景情况:
- 高水平的肝素与低级炎症和铁的减少有关.
- 替代疗法 (TRT) 对炎症和心血管疾病 (CVD) 风险的影响尚不清楚.
- 研究TRT对肝素,FGF23和calprotectin等炎症标志物的作用对于了解心血管疾病风险至关重要.
研究的目的:
- 确定TRT对2型糖尿病男性肝素-铁,FGF23-酸盐-klotho和calprotectin通路的影响.
- 评估TRT是否影响炎症性心血管风险标志物.
- 探索TRT的潜在的直接或间接抗炎机制.
主要方法:
- 这是一项为期24周的随机,安慰剂控制,双盲研究.
- 参与者包括39名患有2型糖尿病和低水平的男性 (50-70岁).
- 测量结果包括血清肝素,铁,FGF23,酸盐,klotho,calprotectin和身体组成.
主要成果:
- 与安慰剂相比,TRT显著降低了肝素水平 (p < 0.001) 和增加了瘦体质 (p = 0.001),同时减少了脂肪质量 (p = 0.009).
- 肝素的变化与肌肉质量或脂肪质量的变化没有相关性.
- 血清铁,FGF23-酸盐-klotho和calprotectin水平在TRT时保持不变.
结论:
- 在患有2型糖尿病的男性中,TRT有效降低了肝素水平.
- 在TRT期间观察到的肝素的减少是独立于铁含量,瘦体质或脂肪质量的变化.
- 这些发现表明,TRT可能会产生直接的抗炎作用,而不是通过铁或身体成分介导的间接作用.
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