乳酸盐:过度简单化的谬论
Jiri Müller1, Jaroslav Radej1, Jan Horak1
1Department of Internal Medicine, Faculty of Medicine in Pilsen, Charles University, Teaching Hospital Pilsen, Alej Svobody 80, 32300 Pilsen, Czech Republic.
乳酸盐,经常被错误地视为废物,即使在有氧条件下,也对细胞功能至关重要. 了解乳酸盐的理解
科学领域:
- 生物化学 生物化学
- 细胞的新陈代谢
背景情况:
- 牛奶酸由卡尔·威廉·舍利 (Carl Wilhelm Scheele) 发现,与一百多年前被确立的休克中缺氧的联系.
- 通常被误认为仅仅是无氧代谢的副产品和危险标志物.
- 关于乳酸的作用,仍然存在着根深蒂固的神话和误解.
研究的目的:
- 揭穿围绕乳酸的常见误解.
- 澄清乳酸在细胞代谢和生理条件中的真正作用.
- 为了突出解释高乳糖血症的复杂性.
主要方法:
- 审查现有的科学文献和已确定的生化途径.
- 分析乳酸在无氧代谢之外的生理作用.
- 通过科学证据揭穿普遍的神话.
主要成果:
- 乳酸被细胞连续生产和利用,即使在有氧条件下.
- 超乳酸血症并不总是危及生命的症状,也不是所有重症患者都患有超乳酸血症.
- 乳酸盐不会独立引起酸性疾病,无毒,并具有有益的特性.
结论:
- 乳酸是具有多种生理功能的关键分子,不仅仅是废物.
- 解释高乳糖血症需要一个细微的理解超出了简单的无氧代谢.
- 挑战关于乳酸的根深蒂固的信念对于准确的临床评估至关重要.
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