CPAP治疗对自主神经系统的影响
Tea Friščić1, Domagoj Vidović2,3,4, Igor Alfirević1
1Department of Cardiovascular Diseases, Clinical Hospital Sveti Duh, 10000 Zagreb, Croatia.
Biomedicines
|December 23, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 破坏自主神经系统 (ANS),增加心血管风险. 持续的阳性气道压力 (CPAP) 治疗改善了ANS功能,特别是在夜间,有利于高血压患者.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 神经科学是一个神经科学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种与心血管疾病 (CVD) 相关的普遍疾病.
- 自主神经系统 (ANS) 失调是OSA相关心血管疾病发展的关键机制.
- 了解OSA中的ANS功能及其对治疗的反应对于预防心血管疾病至关重要.
研究的目的:
- 在患有严重阻塞性睡眠呼吸暂停 (OSA) 的患者中调查自主神经系统 (ANS) 功能.
- 评估长期连续正气道压力 (CPAP) 治疗对ANS参数的影响.
- 为了确定从CPAP治疗中获得最多益处的患者子组,关于ANS改善.
主要方法:
- 预期和受控队列研究设计.
- 包括57名新诊断的严重OSA患者.
- 在37名坚持治疗的患者中,对CPAP治疗前6个月和之后的24小时霍尔特心电图和门诊血压监测的分析.
主要成果:
- 通过CPAP治疗,可显著降低夜间透气血压.
- 夜间心率变化参数 (SDNN,RMSSD) 在CPAP后下降.
- 在CPAP治疗后,白天的光谱功率增加,而夜间的光谱功率 (VLF,LF,HF频段) 减少.
结论:
- 严重的OSA与ANS失衡有关,表现出同情性占主导地位,特别是在夜间和高血压患者中.
- CPAP疗法对ANS功能产生了积极影响,在夜间时间观察到更大的改善.
- CPAP对ANS参数的益处在男性和患有动脉高血压的患者中更为明显.
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