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细胞因子网络的叙述性综述:炎症性肠病的病理生理和治疗影响炎症性肠病的发病因子

Marek Vebr¹, Renáta Pomahačová¹, Josef Sýkora¹

¹Departments of Pediatrics, Faculty Hospital, Faculty of Medicine in Pilsen, Charles University of Prague, 323 00 Pilsen, Czech Republic.

|December 23, 2023

概括

炎症性肠病 (IBD) 涉及复杂的细胞因子网络. 了解这些免疫信号通路对于开发针对克罗恩病和性结肠炎的向疗法至关重要.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
分子生物学分子生物学

背景情况:

炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),是一种慢性免疫介导的炎症状况,其致病性不完全理解.
细胞因子由各种免疫细胞产生,形成复杂的信号网络,在调节免疫反应和组织平衡中发挥中心作用.

研究的目的:

审查目前对细胞因子生物学及其在IBD病变发生中的作用的理解.
总结现有和新兴的细胞因子向治疗策略来管理IBD.
为了突出新疗法的需要,由于治疗阻力在一个重要的患者群体.

主要方法:

综合性文献综述,重点关注IBD中的促炎和抗炎细胞因子.
在IBD的背景下对细胞因子网络重塑的分析.
评估当前的治疗干预措施和开发策略,用于细胞因子向治疗.

主要成果:

细胞因子对于维持组织平衡至关重要,它们的失调有助于IBD.
细胞因子网络在IBD中被显著重塑,为有针对性的干预提供了机会.
市场上针对细胞因子的生物药物已经显示出有效性,但诸如不响应性和耐药性等挑战需要新的治疗方法.

结论:

细胞因子及其受体是IBD管理中验证的治疗点.
虽然目前的细胞因子向疗法已经推进了IBD治疗,但仍然存在对新型和个性化疗法的重大未满足需求.
对免疫反应和细胞因子网络的进一步研究对于开发IBD安全有效的向生物疗法至关重要.

关键词:

细胞因子细胞因子炎症性肠病是一种炎症性肠病.新的治疗目标新的治疗目标

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