探索血腺素,性别和严重疾病的潜在疾病之间的关系
Patricia Mester1, Ulrich Räth1, Stephan Schmid1
1Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious Diseases, University Hospital Regensburg, 93053 Regensburg, Germany.
系统性炎症反应综合征 (SIRS) 和败血症中的血腺素水平因潜在疾病和性别而异. 肝硬化会升高脂肪素,而在非肝硬化的女性中,它会升高脂肪素.
科学领域:
- 内分泌学和新陈代谢学
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 素,一个具有免疫调节作用的关键代谢激素,在全身炎症反应综合征 (SIRS) 和败血症中显示出相冲突的水平.
- 有限的研究存在于SIRS/败血症的性别特异性皮素关联,尽管典型的女性偏见较高水平.
- 肝硬化等潜在疾病显著影响患者对感染和代谢概况的易感性.
研究的目的:
- 调查156名SIRS/败血症患者的血亚迪波涅克丁水平,体重指数 (BMI),性别,疾病严重程度和病因因素之间的关系.
- 在危急疾病的背景下,探索腺素调节的性别特异性.
主要方法:
- 在156名SIRS/败血症患者 (包括肝硬化患者) 中测量了血腺素度.
- 统计分析探讨了与BMI,性别,疾病严重程度 (SIRS,败血症,败血症休克) 和特定疾病 (肝硬化,胰腺炎,COVID-19) 的相关性.
- 多变量分析确定了男性和女性血腺素水平的预测因素.
主要成果:
- 在肝硬化患者中,不论性别,都观察到阿迪波涅丁的升高.
- 在非肝硬化患者中,与对照组相比,女性的腺素素水平较低,与BMI相反相关.
- 严重急性呼吸系统综合征冠状病毒2型 (SARS-CoV-2) 感染仅在女性中降低了平内素;较高的平内素趋势与非生存,特别是在男性中.
结论:
- 潜在的疾病和性别显著影响SIRS/败血症患者的血腺素水平.
- 女性的BMI和男性的C-反应蛋白 (CRP) 成为阿迪波内克水平的预测指标.
- 研究结果表明,在SIRS/败血症的预后和管理中,阿迪波内克丁可能具有性别特异性的作用.
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